The ImmunoAge Atlas

An interactive research atlas mapping the frontier of senolytics, biological aging clocks, and longevity science. Live data from ClinicalTrials.gov. Updated February 2026.

β€”
Active Trials
24
Senolytic Compounds
6
Aging Clocks
15+
Companies
πŸ“‘ Live Data

Clinical Trials Tracker

Real-time data from ClinicalTrials.gov API. Tracking senolytic, aging, and longevity interventional trials worldwide.

Fetching from ClinicalTrials.gov...
πŸ’Š Drug Intelligence

Senolytic Drug Comparison

Comprehensive comparison of senolytic compounds. Evidence levels based on published research, clinical trials, and the Nature Aging comparative analysis (2025).

All Compounds
Small Molecules
Biologics
Natural Products
Cell Therapies
πŸ”¬ Science

How Senolytics Work

Cellular senescence is a fundamental driver of aging. Understanding the cascade from trigger to therapy.

The Senescence Cascade

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Triggers
DNA damage, telomere shortening, oncogene activation, oxidative stress, mitochondrial dysfunction
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Cell Cycle Arrest
p53/p21 and p16INK4a/Rb pathways halt cell division permanently
πŸ”₯
SASP
Senescence-Associated Secretory Phenotype: IL-6, IL-8, MMPs, VEGF β€” chronic inflammation
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Tissue Damage
Paracrine senescence spreads, immune evasion, stem cell exhaustion, fibrosis
πŸ’Š
Senolytic Clearance
Targeted elimination of senescent cells restores tissue function and reduces inflammation

Senolytic Target Pathways

The SASP β€” Why Senescent Cells Are Dangerous

πŸ”΄
Inflammatory Cytokines
IL-6, IL-8, IL-1Ξ², TNF-Ξ± β€” drive chronic systemic inflammation ("inflammaging")
βœ‚οΈ
Matrix Metalloproteinases
MMP-1, MMP-3, MMP-9 β€” degrade extracellular matrix, destroy tissue architecture
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Growth Factors
VEGF, HGF, PDGF β€” promote angiogenesis, can fuel tumor growth
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Chemokines
CXCL1, CCL2, CCL5 β€” recruit immune cells, create feedback loops
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Exosomes
Cell-derived vesicles spread senescence signals to distant tissues
🧬
Transposon Activation
Ancient viral DNA reactivates with age, triggering cGAS-STING innate immune response
⏰ Biomarkers

Biological Aging Clocks

Epigenetic clocks measure biological age from DNA methylation patterns. Different clocks capture different aspects of aging. Understanding them is key to measuring whether interventions actually work.

Clock Accuracy Comparison (Correlation with Chronological Age)
What Each Clock Measures
🏒 Market Intelligence

Longevity Company Landscape

Who's building the future of longevity? Funding, focus areas, and pipeline stages of the leading companies.

Total Funding by Company ($M)
Pipeline Distribution by Stage
πŸ“Š Analytics

Research Landscape Analytics

Publication trends, trial distribution, and funding dynamics in the longevity space.

Senolytic Publications by Year (PubMed)
Trial Distribution by Therapeutic Target
Senolytic Mechanism Classes β€” Efficacy vs Safety
Longevity Funding by Year ($M)